Dr. Yuye Ling, Columbia University in the City of New York
Feb 23, 2018, Fri, 10:30-11:30
Mucociliary clearance (MCC) is one of the most important self-defense mechanisms in human respiratory system. The failure of MCC often leads to chronical infections and impaired lung function. The study of MCC requires a thorough understanding of the underlying ciliary activities. Conventional ways of analyzing MCC or ciliary activities are either indirect or qualitative. Optical coherence tomography (OCT), on the other hand, is a promising candidate for quantitative in-vivo imaging. In this presentation, I will discuss the results that were observed on ex-vivo human tracheobronchial ciliary activities by using high-speed OCT. Various functional imaging methods including speckle variance, temporal frequency analysis, phase variance/difference, and frequency-constrained robust principal component analysis (FC-RPCA) are used to characterize ciliary functions such as cilia coverage, ciliary beating frequency, and metachronal wave.
Dr. Yuye Ling is currently a Postdoctoral Research Scientist in Columbia University. He received his PhD degree in Electrical Engineering from the same institute in 2017. He received his BE degree in Information Engineering from Shanghai Jiao Tong University in 2011, and MS degree in Electrical Engineering from University of California, Los Angeles (UCLA) in 2013. He has been awarded Shanghai Municipal Outstanding Graduate (2011), Wei Family Private Foundation Scholarship (2013), and Millman Teaching Assistant Award (2014). His research interests include optical system development, coherence and nonlinear optics, biomedical imaging, digital imaging processing, and related interdisciplinary research.